The Book of Ryan is a continuation of the series The Chronicles of a New World that details the lives of a select few people living in post-apocalyptic America. The story opens and follows Ryan Bayer after the end of A New World. It is also a part of a parallel trilogy along with The Book of Roland and The Book of Niik.
The story starts out with Ryan awakening from a coma in a room full of animal heads. In his attempt to escape he runs into Sage, the Temptress vampire from A New World, who informs him that she infected him with the vampirism virus to save his life. She then tries to keep Ryan in the hunting lodge, claiming that it is for his own good.